What Are The Significance Of Long Non-Coding Rnas In...

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Overexpression of the long non-coding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia. Journal of hematology oncology. 2015;8(1):126. 14. Bassett AR, Akhtar A, Barlow DP, Bird AP, Brockdorff N, Duboule D, et al. Considerations when investigating lncRNA function in vivo. Elife. 2014;3:e03058. 15. Cheetham S, Gruhl F, Mattick J, Dinger M. Long noncoding RNAs and the genetics of cancer. British journal of cancer. 2013;108(12):2419-25. 16. Yao Y, Li J, Wang L. Large intervening non-coding RNA HOTAIR is an indicator of poor prognosis and a therapeutic target in human cancers. International journal of molecular sciences. 2014;15(10):18985-99. 17. Castanotto D, Lin M, Kowolik C, Wang L, Ren X-Q, Soifer HS, et al. A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells. Nucleic acids research. 2015;43(19):9350-61. 18. Soifer HS, Koch T, Lai J, Hansen B, Hoeg A, Oerum H, et al. Silencing of gene expression by gymnotic delivery of antisense oligonucleotides. Functional Genomics: Methods and Protocols. 2012:333-46. 19. Fazil MHUT, Ong ST, Chalasani MLS, Low JH, Kizhakeyil A, Mamidi A, et al. GapmeR cellular internalization by macropinocytosis inducesShow MoreRelatedDevelopment Of The Mammary Gland9524 Words   |  39 Pagesthe correct morphology of duct requires extracellular matrix which together with fibroblasts, endothelial cells, macrophages, and adipocytes, constitute mammary stroma. Fat fills the spaces between the lobules and ducts. 1.2 Mammary gland development Development of the mammary gland starts during embryogenesis but takes several years to complete; indeed, they are still primitive structures that are not yet connected to the nipple, therefore are not functional at birth (Anderson and Clarke). 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